> For the complete documentation index, see [llms.txt](https://docs.hits.ai/hyperlab-release-note-en/llms.txt). Markdown versions of documentation pages are available by appending `.md` to page URLs; this page is available as [Markdown](https://docs.hits.ai/hyperlab-release-note-en/mainfeature_en/hyperlab-main-feature-update-history.md).

# HyperLab Main Feature Update History

## 1. Hyper Binding

<table><thead><tr><th>Update Date</th><th>HyperLab Version</th><th>Changelog</th><th>Description</th><th data-hidden>Release Note</th></tr></thead><tbody><tr><td>March 28, 2024</td><td>2024.03.28</td><td>ES update</td><td><ol start="1"><li><strong>Exhaustive Search</strong>, our brand-new development of a binding-pose search method, and</li><li><strong>PIGNet2</strong>, our published AI for predicting protein-ligand interactions [<a href="https://doi.org/10.1039/D3DD00149K">Digital Discovery 3: 287 (2024)</a>].</li><li>Exhaustive Search significantly increases both Hyper Binding's accuracy and speed.</li></ol></td><td><a href="https://docs.hyperlab.hits.ai/hyperlab-release-note-en/2024-03-28-release-note">https://docs.hyperlab.hits.ai/hyperlab-release-note-en/2024-03-28-release-note</a></td></tr><tr><td>October 18, 2024</td><td>2024.10.18</td><td>Improved Hyper Binding success rate</td><td>The calculation success rate of Hyper Binding has been enhanced.</td><td></td></tr><tr><td>November 15, 2024</td><td>2024.11.15</td><td>Improved ligand ionization handling</td><td>Corrected the ionized forms of some functional groups of ligands.</td><td><a href="https://docs.hyperlab.hits.ai/hyperlab-release-note-en/2024-11-15-release-note">https://docs.hyperlab.hits.ai/hyperlab-release-note-en/2024-11-15-release-note</a></td></tr><tr><td>April 10, 2025</td><td>2025.04.10</td><td>Update with applied Box size calculation method</td><td>For proteins registered as <strong>3D Structure</strong> type, the box size you set is now more precisely reflected in calculations.</td><td><a href="https://docs.hyperlab.hits.ai/hyperlab-release-note-en/2025-04-10-release-note">https://docs.hyperlab.hits.ai/hyperlab-release-note-en/2025-04-10-release-note</a></td></tr><tr><td>February 24, 2026</td><td>2026.02.24</td><td>New support for Covalent Binding calculation</td><td>Covalent binding studies are now available using registered Covalent 3D-type proteins.</td><td></td></tr></tbody></table>

## 2. Hyper ADME/T

<table><thead><tr><th>Update Date</th><th>HyperLab Version</th><th>Changelog</th><th>Description</th><th data-hidden>Release Note</th></tr></thead><tbody><tr><td>October 18, 2024</td><td>2024.10.18</td><td>Changes to the Metabolic stability</td><td>The Metabolic stability in Hyper ADME/T is now changed to Metabolic stability (H/M).</td><td><a href="https://docs.hyperlab.hits.ai/hyperlab-release-note-en/2024-10-18-release-note">https://docs.hyperlab.hits.ai/hyperlab-release-note-en/2024-10-18-release-note</a></td></tr><tr><td>September 25, 2025</td><td>2025.09.25</td><td>New Properties Added</td><td>The items <strong>LogD at pH 7.4</strong> and <strong>CNS MPO</strong> have been newly added.</td><td></td></tr></tbody></table>

## 3. Hyper Design

<table><thead><tr><th>Update Date</th><th>HyperLab Version</th><th>Changelog</th><th>Description</th><th data-hidden>Release Note</th></tr></thead><tbody><tr><td>August 30, 2024</td><td>2024.08.30</td><td>Changing the physicochemical property values of some molecules</td><td>The physicochemical property values of ionizable molecules added by hyperdesign have been changed.</td><td><a href="https://docs.hyperlab.hits.ai/hyperlab-release-note-en/2024-08-30-release-note">https://docs.hyperlab.hits.ai/hyperlab-release-note-en/2024-08-30-release-note</a></td></tr><tr><td>October 18, 2024</td><td>2024.10.18</td><td>Added R group definition feature</td><td>In Hyper Design, you can now define the fragment design to a specific R-group.<br>(Examples of R-groups: Aliphatic chains, Aryl, Heteroaryl, etc.)</td><td><a href="https://docs.hyperlab.hits.ai/hyperlab-release-note-en/2024-10-18-release-note">https://docs.hyperlab.hits.ai/hyperlab-release-note-en/2024-10-18-release-note</a></td></tr><tr><td>November 15, 2024</td><td>2024.11.15</td><td>Performance improvement</td><td><ol start="1"><li>The multiple selection bug in the fragment library has been fixed.</li><li>The Hyder Design algorithm has been improved to allow ‘Add’ feature to bond with carbons that have double bonds.</li></ol></td><td><a href="https://docs.hyperlab.hits.ai/hyperlab-release-note-en/2024-11-15-release-note">https://docs.hyperlab.hits.ai/hyperlab-release-note-en/2024-11-15-release-note</a></td></tr><tr><td>August 28, 2025</td><td>2025.08.28</td><td>User Interface improvement</td><td>When selecting <code>Replace</code>, the selected area and the selectable areas are now clearly distinguished.</td><td></td></tr><tr><td>October 30, 2025</td><td>2025.10.30</td><td>Hyper Design execution method improved</td><td>The structure has been updated to allow Hyper Design to be executed separately for each protein.</td><td></td></tr><tr><td>February 24, 2026</td><td>2026.02.24</td><td>New support for Covalent Binding design</td><td>Hyper Design is now supported for registered COV-type proteins.</td><td></td></tr></tbody></table>

## 4. Hyper Screening

<table><thead><tr><th>Update Date</th><th>HyperLab Version</th><th>Changelog</th><th>Description</th><th data-hidden>Release Note</th></tr></thead><tbody><tr><td>August 9, 2024</td><td>2024.08.09</td><td>PAINS Filter applied</td><td>The PAINS (Pan-Assay Interference Compounds) filter has been applied to the HyperLab library.</td><td><a href="https://docs.hyperlab.hits.ai/hyperlab-release-note-en/2024-08-09-release-note">https://docs.hyperlab.hits.ai/hyperlab-release-note-en/2024-08-09-release-note</a></td></tr><tr><td>February 24, 2026</td><td>2026.02.24</td><td>New support for Covalent Binding calculation</td><td>Covalent-only library screening is now available for registered Covalent 3D-type proteins.</td><td></td></tr></tbody></table>

## 5. 3D Viewer

<table><thead><tr><th>Update Date</th><th>HyperLab Version</th><th>Changelog</th><th>Description</th><th data-hidden>Release Note</th></tr></thead><tbody><tr><td>November 15, 2024</td><td>2024.11.15</td><td>Interaction improvement</td><td>Enhanced to analyze interaction information with DNA/RNA receptors.</td><td><a href="https://docs.hyperlab.hits.ai/hyperlab-release-note-en/2024-11-15-release-note">https://docs.hyperlab.hits.ai/hyperlab-release-note-en/2024-11-15-release-note</a></td></tr></tbody></table>

## 6. Hyper Binding Co-folding

<table><thead><tr><th>Update Date</th><th>HyperLab Version</th><th>Changelog</th><th>Description</th><th data-hidden>Release Note</th></tr></thead><tbody><tr><td>April 10, 2025</td><td>2025.04.10</td><td>New Feature Added</td><td>The Hyper Binding Co-folding feature has been newly added.</td><td><a href="https://docs.hyperlab.hits.ai/hyperlab-release-note-en/2025-04-10-release-note">https://docs.hyperlab.hits.ai/hyperlab-release-note-en/2025-04-10-release-note</a></td></tr><tr><td>October 30, 2025</td><td>2025.10.30</td><td>Performance improvement</td><td>Updated the list of supported PTM cases.</td><td></td></tr><tr><td>February 24, 2026</td><td>2026.02.24</td><td>New support for Covalent Binding calculation</td><td>Covalent binding studies are now available using registered Covalent SEQ-type proteins.</td><td></td></tr></tbody></table>

## 7. Hyper Screening X

<table><thead><tr><th>Update Date</th><th>HyperLab Version</th><th>Changelog</th><th>Description</th><th data-hidden>Release Note</th></tr></thead><tbody><tr><td>April 10, 2025</td><td>2025.04.10</td><td>New Feature Added</td><td>The Hyper Screening X feature has been newly added.</td><td><a href="https://docs.hyperlab.hits.ai/hyperlab-release-note-en/2025-04-10-release-note">https://docs.hyperlab.hits.ai/hyperlab-release-note-en/2025-04-10-release-note</a></td></tr><tr><td>August 11, 2025</td><td>2025.08.11</td><td>Model Performance Improvement</td><td>The model performance of Hyper Screening X has been improved.</td><td></td></tr><tr><td>November 13, 2025</td><td>2025.11.13</td><td>Model Performance Improvement</td><td><p></p><ol start="1"><li>Improved structural diversity in generated molecules after training.</li><li>As of October 2025, unavailable building blocks have been excluded from training and generation results.</li></ol></td><td></td></tr></tbody></table>

## 8. Analysis

| Update Date     | HyperLab Version | Changelog         | Description                                    |
| --------------- | ---------------- | ----------------- | ---------------------------------------------- |
| August 28, 2025 | 2025.08.28       | New Feature Added | The SAR Analysis feature has been newly added. |