> For the complete documentation index, see [llms.txt](https://docs.hits.ai/hyperlab-release-note-en/llms.txt). Markdown versions of documentation pages are available by appending `.md` to page URLs; this page is available as [Markdown](https://docs.hits.ai/hyperlab-release-note-en/changelog_en/2026-02-24-relese-note.md).

# 2026-02-24 Relese Note

The update for HyperLab on Febraury 24, 2026, has been completed.

#### HyperLab Version : 2026.02.24 <a href="#hyperlab-version-2026.02.24" id="hyperlab-version-2026.02.24"></a>

***

## :mega: Changelogs <a href="#changelogs" id="changelogs"></a>

### 1. Official Launch of the Covalent Research Workflow <a href="#id-1.-official-launch-of-the-covalent-research-workflow" id="id-1.-official-launch-of-the-covalent-research-workflow"></a>

The Covalent feature is now officially available, enabling end-to-end Covalent drug research within a single platform in HyperLab.

Covalent research can be conducted through the following workflow:

* Register a Covalent-type protein
* Perform Covalent library-based screening
* Predict Covalent binding for individual molecules
* Analyze structures in the 3D Viewer
* Launch Hyper Design based on Covalent results

Depending on research objectives, each step can be used independently.

### 2. Addition of Covalent Protein Types <a href="#id-2.-addition-of-covalent-protein-types" id="id-2.-addition-of-covalent-protein-types"></a>

COV-type proteins have been added to support Covalent research.

※ Target residue selection is mandatory when registering a Covalent-type protein.

#### 2.1. COV 3D Structure <a href="#cov-3d-structure" id="cov-3d-structure"></a>

<figure><img src="https://709489233-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FUd87mch9xATD0InicbJH%2Fuploads%2FxcMyRBL0XbghhDs9BwX3%2F%E1%84%89%E1%85%B3%E1%84%8F%E1%85%B3%E1%84%85%E1%85%B5%E1%86%AB%E1%84%89%E1%85%A3%E1%86%BA%202026-02-24%20%E1%84%8B%E1%85%A9%E1%84%92%E1%85%AE%2012.29.05.png?alt=media&amp;token=9c0c0cc7-a356-43ea-ac5b-7e93060ec910" alt=""><figcaption></figcaption></figure>

* Import 3D structures using PDB ID or UniProt ID
* Perform Covalent docking based on experimentally determined structures

#### 2.2. COV Sequence <a href="#cov-sequence" id="cov-sequence"></a>

<figure><img src="https://709489233-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FUd87mch9xATD0InicbJH%2Fuploads%2FsHYNtfwdDdc1BNd5pVwb%2F%E1%84%89%E1%85%B3%E1%84%8F%E1%85%B3%E1%84%85%E1%85%B5%E1%86%AB%E1%84%89%E1%85%A3%E1%86%BA%202026-02-24%20%E1%84%8B%E1%85%A9%E1%84%92%E1%85%AE%2012.30.00.png?alt=media&amp;token=e37b4299-f49e-4192-9c52-f16d426aa2ff" alt=""><figcaption></figcaption></figure>

* Generate structures from amino acid sequences
* Support structure prediction using co-folding

### 3. Addition of Covalent Screening <a href="#id-3.-addition-of-covalent-screening" id="id-3.-addition-of-covalent-screening"></a>

A dedicated library-based screening feature designed for Covalent reactions has been added.

<figure><img src="https://709489233-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FUd87mch9xATD0InicbJH%2Fuploads%2FKqIAKmSu2ItJtGauDPrk%2F%E1%84%89%E1%85%B3%E1%84%8F%E1%85%B3%E1%84%85%E1%85%B5%E1%86%AB%E1%84%89%E1%85%A3%E1%86%BA%202026-02-24%20%E1%84%8B%E1%85%A9%E1%84%92%E1%85%AE%201.57.10.png?alt=media&amp;token=f42471db-67a5-4d98-bc35-748505cb196c" alt=""><figcaption></figcaption></figure>

* Automatic filtering of libraries based on the selected target residue
* Execute screening after selecting one or more libraries
* Warhead information is provided as a table field

Accessible via:\
Bench → Fields → Covalent → \[Protein] – Warhead field

### 4. Addition of Covalent Binding <a href="#id-4.-addition-of-covalent-binding" id="id-4.-addition-of-covalent-binding"></a>

Covalent binding prediction for individual molecules is now supported.

<figure><img src="https://709489233-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FUd87mch9xATD0InicbJH%2Fuploads%2FqmhdcZJGxMey3Wb4OowE%2F%E1%84%89%E1%85%B3%E1%84%8F%E1%85%B3%E1%84%85%E1%85%B5%E1%86%AB%E1%84%89%E1%85%A3%E1%86%BA%202026-02-24%20%E1%84%8B%E1%85%A9%E1%84%92%E1%85%AE%202.06.10.png?alt=media&amp;token=a86441b0-c6a7-4888-b772-ddff0b0d2991" alt=""><figcaption></figcaption></figure>

* Easy reaction setup by specifying the Warhead region and selecting a Product form
* Automatic recording of selected Warhead (viewable in the table field)
* Custom Product form creation for flexible research workflows

### 5. Covalent Structure Support in 3D Viewer <a href="#id-5.-covalent-structure-support-in-3d-viewer" id="id-5.-covalent-structure-support-in-3d-viewer"></a>

Covalent Binding and Screening results can be visualized in the 3D Viewer.

<figure><img src="https://709489233-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FUd87mch9xATD0InicbJH%2Fuploads%2F146CICPJE0MFuwlw3PM7%2F%E1%84%89%E1%85%B3%E1%84%8F%E1%85%B3%E1%84%85%E1%85%B5%E1%86%AB%E1%84%89%E1%85%A3%E1%86%BA%202026-02-24%20%E1%84%8B%E1%85%A9%E1%84%92%E1%85%AE%202.09.43.png?alt=media&amp;token=8e4ac378-8ba4-4243-868b-4ca047b1368b" alt=""><figcaption></figcaption></figure>

* View covalent bond structures
* Compare Reactant and Product forms

### 6. Hyper Design Integration with Covalent Results <a href="#id-6.-hyper-design-integration-with-covalent-results" id="id-6.-hyper-design-integration-with-covalent-results"></a>

Hyper Design can be launched directly from Covalent Binding results.

<figure><img src="https://709489233-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2FUd87mch9xATD0InicbJH%2Fuploads%2FabvHLNWcjP8ZLtQ7WTlZ%2F%E1%84%89%E1%85%B3%E1%84%8F%E1%85%B3%E1%84%85%E1%85%B5%E1%86%AB%E1%84%89%E1%85%A3%E1%86%BA%202026-02-24%20%E1%84%8B%E1%85%A9%E1%84%92%E1%85%AE%202.10.31.png?alt=media&amp;token=08b2979d-3dc3-4d23-8886-cfadc8df052a" alt=""><figcaption></figcaption></figure>

* Perform design while preserving the Warhead and binding region
* Explore structures to improve activity and physicochemical properties

***

## :tools: Bug fix <a href="#bug-fix" id="bug-fix"></a>

Bug fixes and stability improvements have been made.