> For the complete documentation index, see [llms.txt](https://docs.hits.ai/hyperlab-use-case/llms.txt). Markdown versions of documentation pages are available by appending `.md` to page URLs; this page is available as [Markdown](https://docs.hits.ai/hyperlab-use-case/use-case/deg-and-kg-usage-for-analyzing-arid1a-mutation-effect-in-breast-cancer.md).

# 007. DEG and KG usage for analyzing ARID1A mutation effect in breast cancer

ARID1A knockout RNA-seq in MCF7 breast cancer cells, with each finding checked against knowledge-graph evidence.

## Use Case in HyperLab

<div align="center"><figure><img src="https://4290995292-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2Fc8jFSx45v33BUSaQuAOW%2Fuploads%2FsvqZLSki9OITMgpMeRFT%2Fuc-84173ece00d8d1d42c9b10b69b7a.png?alt=media" alt="01.png"><figcaption></figcaption></figure></div>

<div align="center"><figure><img src="https://4290995292-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2Fc8jFSx45v33BUSaQuAOW%2Fuploads%2FGLD2k8ZLdydpHeH64Pps%2Fuc-9bf3d1f82ba3c49891ad0817d343.png?alt=media" alt="02.png"><figcaption></figcaption></figure></div>

<div align="center"><figure><img src="https://4290995292-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2Fc8jFSx45v33BUSaQuAOW%2Fuploads%2FmqC9JCJEDCYdM9ZU3VJY%2Fuc-a732803a395f002dce9238187d0c.png?alt=media" alt="03.png"><figcaption></figcaption></figure></div>

<div align="center"><figure><img src="https://4290995292-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2Fc8jFSx45v33BUSaQuAOW%2Fuploads%2FMEXbkwbhXjOd29Ep9Bwt%2Fuc-8c3715c412da538a9bada5529abd.png?alt=media" alt="04.png"><figcaption></figcaption></figure></div>

<div align="center"><figure><img src="https://4290995292-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2Fc8jFSx45v33BUSaQuAOW%2Fuploads%2Fqh8Ps17xV1sQERxDcmo5%2Fuc-81eafa1d55ba2e9a07b6954f74ef.png?alt=media" alt="05.png"><figcaption></figcaption></figure></div>

<div align="center"><figure><img src="https://4290995292-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2Fc8jFSx45v33BUSaQuAOW%2Fuploads%2F9eqHgzOHUcz1dy7AVxRB%2Fuc-a45f914466ba901b935619cb1a9c.png?alt=media" alt="06.png"><figcaption></figcaption></figure></div>

<div align="center"><figure><img src="https://4290995292-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2Fc8jFSx45v33BUSaQuAOW%2Fuploads%2FBSQpfMaYcuon1PJDR2sX%2Fuc-bf63bb1d4cdd7e876a9eeec033cc.png?alt=media" alt="07.png"><figcaption></figcaption></figure></div>

<div align="center"><figure><img src="https://4290995292-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2Fc8jFSx45v33BUSaQuAOW%2Fuploads%2FCEgewSOILCkquoP8h2Jy%2Fuc-47b5f13ff91a062d5911e02385e3.png?alt=media" alt="08.png"><figcaption></figcaption></figure></div>

<div align="center"><figure><img src="https://4290995292-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2Fc8jFSx45v33BUSaQuAOW%2Fuploads%2FjUlCRYAUT88QpzwA7Por%2Fuc-d5eb2087adfbc7f562f919abb522.png?alt=media" alt="09.png"><figcaption></figcaption></figure></div>

<div align="center"><figure><img src="https://4290995292-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2Fc8jFSx45v33BUSaQuAOW%2Fuploads%2F46iI7eu4FtCO9pIZwxk4%2Fuc-fa54f18b554f5e6bba12f3027436.png?alt=media" alt="10.png"><figcaption></figcaption></figure></div>

<div align="center"><figure><img src="https://4290995292-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2Fc8jFSx45v33BUSaQuAOW%2Fuploads%2FAEoryACZ73Keko2Y9ZNm%2Fuc-753866c15f6245f7db3ae08ceaa6.png?alt=media" alt="11.png"><figcaption></figcaption></figure></div>

<div align="center"><figure><img src="https://4290995292-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2Fc8jFSx45v33BUSaQuAOW%2Fuploads%2FfP3Va1wuCzg3M10L3yGf%2Fuc-b1bb373117b6341e4ca6a23563a3.png?alt=media" alt="12.png"><figcaption></figcaption></figure></div>

<div align="center"><figure><img src="https://4290995292-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2Fc8jFSx45v33BUSaQuAOW%2Fuploads%2Fx46avbmVKx5aQjNAPyia%2Fuc-bca3b52d610f5f9c6401f44a4bcf.png?alt=media" alt="13.png"><figcaption></figcaption></figure></div>

<div align="center"><figure><img src="https://4290995292-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2Fc8jFSx45v33BUSaQuAOW%2Fuploads%2FQRXhiTTdJKiTzuRJ7Qwm%2Fuc-260c83d8a1dd1648b4862d0e5f7d.png?alt=media" alt="14.png"><figcaption></figcaption></figure></div>

<div align="center"><figure><img src="https://4290995292-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2Fc8jFSx45v33BUSaQuAOW%2Fuploads%2FjuuJl7ryZJp2dwXbe510%2Fuc-dda661a7955497c171c64534daa7.png?alt=media" alt="15.png"><figcaption></figcaption></figure></div>

## Artifacts

<div align="center"><figure><img src="https://4290995292-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2Fc8jFSx45v33BUSaQuAOW%2Fuploads%2FKQNZ7ipZrK1kS5C0weyT%2Fuc-bfb643999403c9db22491cbc745a.png?alt=media" alt="gsea_plot.png"><figcaption></figcaption></figure></div>

<div align="center"><figure><img src="https://4290995292-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2Fc8jFSx45v33BUSaQuAOW%2Fuploads%2F4wezBRvJLMXWtCOhomXd%2Fuc-1a2a774a02b7bac4992aa95048f0.png?alt=media" alt="knowledge-graph.png"><figcaption></figcaption></figure></div>

<div align="center"><figure><img src="https://4290995292-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2Fc8jFSx45v33BUSaQuAOW%2Fuploads%2FCsrja1IYxyb4TYka9ofw%2Fuc-ed6fd3174cf0afa38dddc0d54652.png?alt=media" alt="volcano.png"><figcaption></figcaption></figure></div>