> For the complete documentation index, see [llms.txt](https://docs.hits.ai/hyperlab-use-case/llms.txt). Markdown versions of documentation pages are available by appending `.md` to page URLs; this page is available as [Markdown](https://docs.hits.ai/hyperlab-use-case/use-case/kg-guided-clinical-trial-design-for-lazertinib-amivantamab-in-egfr-mutant-nsclc.md).

# 005. KG-guided clinical trial design for lazertinib + amivantamab in EGFR-mutant NSCLC

Designing a lazertinib + amivantamab trial for EGFR-mutant NSCLC, with patient selection backed by knowledge-graph evidence.

## Use Case in HyperLab

<div align="center"><figure><img src="https://4290995292-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2Fc8jFSx45v33BUSaQuAOW%2Fuploads%2FLLwhTZYpYzEAxzxleYQR%2Fuc-924bad13b9c5cafb0d8647c266fb.webp?alt=media" alt="01.png"><figcaption></figcaption></figure></div>

<div align="center"><figure><img src="https://4290995292-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2Fc8jFSx45v33BUSaQuAOW%2Fuploads%2FmPBofeCyccRiKp8De9ED%2Fuc-8f9a89617469a8b4503e808e9ee4.png?alt=media" alt="02.png"><figcaption></figcaption></figure></div>

<div align="center"><figure><img src="https://4290995292-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2Fc8jFSx45v33BUSaQuAOW%2Fuploads%2FLMJNTMQXVd1vfcPB8FEl%2Fuc-90828142275a9b46cc9e119cf3d7.webp?alt=media" alt="03.png"><figcaption></figcaption></figure></div>

<div align="center"><figure><img src="https://4290995292-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2Fc8jFSx45v33BUSaQuAOW%2Fuploads%2FSUgouZItLoZrnrUvX918%2Fuc-522983d04d69b64ca9a2acafc087.webp?alt=media" alt="04.png"><figcaption></figcaption></figure></div>

<div align="center"><figure><img src="https://4290995292-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2Fc8jFSx45v33BUSaQuAOW%2Fuploads%2FyroV4EFO3j3LAITAc2Cx%2Fuc-d6c6ab77881b333ebf81c395a706.png?alt=media" alt="05.png"><figcaption></figcaption></figure></div>

<div align="center"><figure><img src="https://4290995292-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2Fc8jFSx45v33BUSaQuAOW%2Fuploads%2FQFAYxgOPRu7mOkvSrzDs%2Fuc-31713983c0ac592e2d3ba57a076b.webp?alt=media" alt="06.png"><figcaption></figcaption></figure></div>

## Artifacts

<div align="center"><figure><img src="https://4290995292-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2Fc8jFSx45v33BUSaQuAOW%2Fuploads%2Ftil7DLEaH1kEnd6otIQS%2Fuc-79f5edf370f7c2ca42907488bf33.png?alt=media" alt="knowledge-graph.png"><figcaption></figcaption></figure></div>

<div align="center"><figure><img src="https://4290995292-files.gitbook.io/~/files/v0/b/gitbook-x-prod.appspot.com/o/spaces%2Fc8jFSx45v33BUSaQuAOW%2Fuploads%2FoJ84muaGs0nvmLtOBaCG%2Fuc-70432e5fd2c6d41df4c113c09c19.webp?alt=media" alt="lazertinib_amivantamab_trial_strategy_summary__707e67.png"><figcaption></figcaption></figure></div>